You certainly can! As each design will require a separate artwork and print set up, each different design needs to be placed as a separate order. You can add the items separately to your basket and checkout as one order and one payment, but the items need to be separate within your basket. For example, if you want 10 T-Shirts with one design and 15 T-shirts with a separate design, these needs to show as two separate items of 10 and 15, rather than one of 25 T-Shirts in your basket.
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